For premenopausal women, tamoxifen may be combined with ovarian suppression
3 min read Tamoxifen is a medication that blocks the female hormone estrogen in the body
Tamoxifen is a drug used to treat breast cancer in both premenopausal women (women who have not yet gone through the menopause) and postmenopausal women
Tamoxifen, AIs, elacestrant, and fulvestrant can be used to treat more advanced hormone-positive breast cancers, especially in post-menopausal women
For premenopausal women, tamoxifen may be combined with ovarian suppression
Tamoxifen citrate is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems
Tamoxifen (Nolvadex® or Soltamox®) is a drug that treats hormone receptor-positive (hormone-positive) breast cancer
Tamoxifen has been considered as a chemopreventive agent to reduce the incidence of breast cancer in women at high risk of breast cancer
N-Desmethyltamoxifen has biologic activity similar to that of the parent drug
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Tamoxifen's labeling notes that the drug should not be used with drugs that prolong the QT interval
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Article CAS PubMed Google Scholar Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, et al
Tamoxifen (TAM)-inducible Cre/loxP is one of the most widely used inducible systems for gene regulation
Schema of the NSABP B-21 trial evaluating the role of tamoxifen, breast radiotherapy (XRT) and combination of the two in patients with invasive breast cancer ≤1 cm in size treated with lumpectomy and comparison of the 8-year cumulative incidence of ipsilateral breast tumor recurrence (IBTR) rates between the three groups
Piltz JR, Wertenbaker C, Lance SE, et al
Although menopausal symptoms may become less frequent and less intense over time, they can still be hard to manage
We investigated the effect of MCT inhibition in combination with 4-hydroxytamoxifen (4-OHT), an active metabolite of tamoxifen, using two estrogen receptor (ER)-positive breast cancer cell lines, MCF-7 and T47D