Dosage ranges for the strongly recommended SSRIs are: sertraline (Zoloft) 50 mg to 200 mg daily; paroxetine (Paxil) 20 to 60 mg daily Several studies have
Background: Prazosin has been an accepted treatment for patients with post-traumatic stress disorder (PTSD) who experience sleep disturbances, including nightmares
3 days in the prazosin group and 28
The recommended starting dose to minimise the risk of adverse drug reactions (ADRs) is 1 mg before bed, increasing by 1 mg every 2–3 nights until a clinical response is obtained
In the available literature, prazosin has been initiated at 1 mg nightly, with titration to effect, and a mean daily dose of 3
61% of reviewers reported a positive experience, while 24% reported a negative experience
Results: A total of 9 published articles related to the use of prazosin for treatment of nightmares in PTSD in children and adolescents were identified
who had previously been prescribed psychotropic medications for the treatment of PTSD-related nightmares
1,2 Because it has a half-life of only 2 to 3 hours and a duration of action of 6 to 10 hours, multiple daytime doses are required
0 mg
PTSD is a psychiatric disorder with several characteristic symptoms including flashbacks, nightmares, avoidance, and hypervigilance due to trauma(s)
At 75 to 100 mg/d in a clinical trial, topiramate partially or completely suppressed nightmares
Doxazosin is a "me-too" drug of prazosin
The dose range of prazosin was 1-15 mg at every bedtime (0
Taken together, the divergence in the findings regarding prazosin Indications and dose For prazosin Hypertension for prazosin By mouth
To date, the highest reported dose of prazosin used for PTSD is 16 mg daily
Dual antagonism of this receptor would be expected to increase risk of
Our search yielded 21 studies, consisting of 4 RCTs, 4 open-label studies, 4 retrospective chart reviews, and 9 single case reports
To the Editor: There have been numerous studies on the use of prazosin for nightmares, but data on doxazosin are very limited
— Mayo Clinic researchers this week will announce the use of the blood pressure drug prazosin as an effective treatment to curb post-traumatic stress disorder (PTSD)-related nightmares