In 2023 in the U
Because spironolactone has estrogenic effects, there is a theoretical risk for BC recurrence
The treatment included a histone deacetylase (HDAC) inhibitor — a drug that causes a chemical change to stop tumor cells from dividing — with two types of immunotherapy known as Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile
No statistically significant association was observed between
Three studies included in the analysis provided data on the risk of breast
Spironolactone is used off-label for androgenic alopecia because of its
Spironolactone has endocrine effects that could influence cancer risks
1136/bmj
It's well-known that carrying certain variants of the BRCA1 or BRCA2 gene
sores, welts, or blisters
It can treat conditions like heart failure and high blood pressure
2019;174(1):15-26
In the rodent study, two years of ingesting spironolactone (at 25–250 times the exposure dose in humans) resulted in benign adenomas of the thyroid and testes, malignant mammary tumors, and proliferative changes in the liver
Hazard ratios (HRs) for cancer recurrence were calculated using Cox proportional hazard models
As with breast enlargement caused by spironolactone in women, gynecomastia due to spironolactone in men is often although inconsistently accompanied by breast tenderness
So, I guess the end result is a slightly raised estradiol level, which may slightly increase breast cancer risk This risk shouldn't be significant (your endocrinologist probably concluded that the risk is negligible)
It blocks male sex hormone receptors — also called androgen receptors
It is used to treat high blood pressure
The unadjusted incidence rates of breast cancer in women who had received spironolactone (n = 28,032) and those who had not (55,961 age-matched individuals) were 0
Spironolactone for the treatment of endocrine therapy–induced alopecia in breast cancer survivors was not associated with increased risk of recurrence of the malignancy in a large retrospective study, Chapman Wei said in a in a virtual meeting held by the George Washington University department of dermatology in Washington
There are 110,029 people reported to have side effects when taking Spironolactone
Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile
Spironolactone inhibits the action of aldosterone by binding to specific receptors in the kidney where aldosterone controls the balance of salt and water in the body
These studies have not suggested an increased risk of cancer in spironolactone users who are at low risk for breast cancer