There is a need for effective treatment for coronavirus disease 2019 (COVID-19) infection
During Chloroquine treatment period, we observed 5 patients who experienced a total of 9 adverse events, including vomiting, abdominal pain, nausea
In-vitro studies have shown that chloroquine is effective against several viruses, including severe acute respiratory syndrome coronavirus (SARS-CoV)
Hydroxychloroquine and chloroquine inhibit SARS-CoV-2 in vitro, and a Chinese commentary, mentioning 15 trials, reported that, “Thus far, results from more than 100
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged
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Led by University Distinguished Professor Linsey Marr (seated), an interdisciplinary research team has recently made great strides in developing a
Abstract
The new research, by the Global Vaccine Data Network, was published in the journal Vaccine last week, with the data made available via interactive dashboards to
17 to March 2 is 16, or "severe," data from COVID-19 Resources Canada shows
Facts, fiction and the hype: a critical appraisal - PMC Journal List Elsevier - PMC
We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro
Chloroquine is an amine acidotropic form of quinine that was synthesised in Germany by Bayer in 1934 and emerged approximately 70 years ago as an effective substitute for natural quinine [1,2]
These drugs have potential broad-spectrum antiviral
Caused by a new virus, SARS-CoV2, COVID-19 is related to the common cold and the SARS-CoV1 virus that was responsible for the 2003 Severe Acute Respiratory Syndrome (SARS) infection in Asia, causing about
Based on an evaluation of the scientific data to date, the FDA concluded that chloroquine and hydroxychloroquine are not likely to be effective in the treatment of COVID-19 for the authorized uses in the EUA
5, 6 A Chinese commentary reported early favorable results in placebo-controlled trials of chloroquine treatment of COVID-19, 7 and based on this early data, the Department of Science and Technology of Guangdong
The antiviral effects of CQ and HCQ have been demonstrated in vitro due to
In-vitro studies have shown that chloroquine is effective against several viruses, including severe acute respiratory syndrome coronavirus (SARS-CoV)
Treating COVID-19 with Chloroquine J Mol Cell Biol
The media have featured the antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) to treat coronavirus (COVID-19)
, 2020: 11: Two tablets chloroquine phosphate twice daily: Critically ill COVID-19 pneumonia: Cortegiani et al
Results: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells
Added value of this study In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19
As of April 22, 2020, more than 2
Conclusions: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19