Certain agents, particularly those used for chemotherapy and regulation of
48), nor did the rate of overall adverse events (41
Omeprazole is used to treat excess stomach acid in conditions such as non cancerous stomach ulcers, gastroesophageal reflux disease , active duodenal ulcer
24, 95% CI: 1
21 –
The majority of primary care physicians who prescribe proton pump inhibitors like omeprazole don’t inform patients they need to take the medication 30 minutes
Here, the PPI undergoes acid-catalyzed cleavage of a chiral sulfoxide bond (except esomeprazole and dexlansoprazole which are nonchiral) into active sulfenic acid and/or sulfonamide
Platelets are blood cells that help in blood clotting and wound healing — risks
8 –10,12 In some of these case reports, thrombocytopenia recurred after reexposure to the culprit drug as seen in the present case
Case summary: An 85-year-old white man presented with an upper gastrointestinal hemorrhage from a gastric ulcer
Thrombocytopenia is a platelet count of less than 150 × 103 per μL and can occur from decreased platelet production, increased destruction, splenic sequestration, or dilution or clumping The label for clopidogrel warns physicians to “avoid concomitant use of
g
Thrombocytopenia might occur as a result of a bone marrow disorder such as leukemia or an immune system
It is our opinion that clopidogrel monotherapy should be administered to ACS patients with thrombocytopenia who are not undergoing PCI if their platelet count is <100 × 10 9 /L but ≥50 × 10 9 /L and in the absence of bleeding (Figure 2)
It works by decreasing the amount of acid produced by the stomach
29 A small, prospective trial of patients with acute myocardial infarction found that platelet function, assessed using the Verify Now system, was significant higher in patients who received omeprazole versus People with mild immune thrombocytopenia might need only regular platelet checks
In vitro studies have shown that a high intragastric pH could facilitate platelet aggregation
Thrombocytopenia has not been found to be a significant side effect of PPI use
In humans, the concurrent use of these two drugs can reduce the anti-platelet efficacy of clopidogrel
for English language studies was conducted using key terms PPI: omeprazole mood or mental changes
pain or swelling in the arms or legs without any injury
4% with placebo, P=0