There are no systematically collected data to specifically address switching patients from other antipsychotics to risperidone long-acting injection (RLAI)
1 We describe a patient with acute worsening of psychotic Objective: This study was a comparative investigation of the effects on clinical symptoms and cognitive function of switching the treatment of schizophrenia patients from haloperidol decanoate depot to risperidone long-acting injection (RLAI) compared with a control group that continued receiving haloperidol decanoate depot
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While one of the most frequently employed combinations is aripiprazole and clozapine, the clinical and pharmacological effects of coadministration of aripiprazole and haloperidol remains
7 percentage points of D 2 occupancy
(Abilify Maintena haloperidol, risperidone, zuclopenthixol) are reduced Reference Lisbeth Haldol (haloperidol lactate inj) Schizophrenia 2–5mg IM every 4–8 hrs or up to hourly if needed — Switch to oral form 12–24 hrs after last injection Trifluoperazine HCl (tabs) Psychosis 2–5mg twice daily 15–20mg/day — Abilify (aripiprazole tabs
1,2 When a patient fails to respond to an adequate dose and duration of an initial antipsychotic, switching to an antipsychotic other than clozapine is generally recommended
For an overview, see the guidance for using Risperdal Consta
Abilify is also used to treat bipolar disorder, irritability associated with autistic disorder, and it is used with other medications to treat major depression in adults
Guidance produced by Nicola Greenhalgh Lead clinical pharmacist MHS, March 2020 V1
It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors
During switching: don't reduce anticholinergics; consider adding oxazepam